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Mechanistically, it activates Nrf2 and its nuclear translocation, thereby enhancing the expression of downstream antioxidant genes to relieve oxidative stress

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Ogt assumes a critical role in the establishment of excitatory synapses, in part by selectively modulating the synaptic abundance of GluA2 and GluA3 subunits, pivotal constituents of AMPARs [31]

doi: 10.1016/j.febslet.2006.04.088 224 ZoccolellaSTortorellaCIaffaldanoPDirenzoVD'OnghiaMPaolicelliDet al